Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. - Wikidata - wikimedia - TriplyDB

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

http://www.wikidata.org/entity/Q36190681

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Targeting inflammation in pancreatic cancer: Clinical translation The gastrointestinal tumor microenvironment Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis Chemokine receptor-specific antibodies in cancer immunotherapy: achievements and challenges Duality of the immune response in cancer: lessons learned from skin CXCR2: a target for pancreatic cancer treatment?Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy Genetically engineered mouse models in oncology research and cancer medicine The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment TIGAR is required for efficient intestinal regeneration and tumorigenesis Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.The role of neutrophil myeloperoxidase in models of lung tumor development.Tumor associated macrophages and neutrophils in tumor progression.Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2 Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer.Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer.CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-κB activation via EGFR-transactivated Akt signaling Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells Resistance of R-Ras knockout mice to skin tumour induction Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease.Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases.Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.The role of tissue resident cells in neutrophil recruitment Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression.CXCR2-CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma.Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice.Phorbol ester-induced neutrophilic inflammatory responses selectively promote metastatic spread of melanoma in a TLR4-dependent manner Host Cxcr2-dependent regulation of mammary tumor growth and metastasis

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P2860

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

http://www.wikidata.org/entity/Q36190681

description

2012 nî lūn-bûn

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name

Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Inhibition of CXCR2 profoundly ...... and spontaneous tumorigenesis.

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Andreas Jung

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Colin W Steele

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Jens Neumann

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Sudipto Das

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Thomas Jamieson

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P2860

CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3

Autophagy mediates the mitotic senescence transition

Cancer in inflammatory bowel disease

Inflammation and cancer

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Cancer-related inflammation

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

Tumor entrained neutrophils inhibit seeding in the premetastatic lung

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3127-3144

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10.1172/JCI61067

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9

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122

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Michael S. Samuel

Michael F. Olson

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2012-08-27T00:00:00Z

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230741208

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22922255

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3428079

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