Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
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Human INT6/eIF3e is required for nonsense-mediated mRNA decayReconstitution reveals the functional core of mammalian eIF3PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunitsPCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexesThe human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasomeInt6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeastThe proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.Hypoxia-inducible factor as an angiogenic master switchINT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits.Activation of AP-1-dependent transcription by a truncated translation initiation factor.Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h.The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits.
P2860
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P2860
Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
Fission yeast homolog of murin ...... anslation initiation factor 3.
@en
Fission yeast homolog of murin ...... anslation initiation factor 3.
@nl
type
label
Fission yeast homolog of murin ...... anslation initiation factor 3.
@en
Fission yeast homolog of murin ...... anslation initiation factor 3.
@nl
prefLabel
Fission yeast homolog of murin ...... anslation initiation factor 3.
@en
Fission yeast homolog of murin ...... anslation initiation factor 3.
@nl
P2093
P2860
P356
P1476
Fission yeast homolog of murin ...... anslation initiation factor 3.
@en
P2093
Akiyoshi Y
Hinnebusch AG
Watanabe Y
Yamamoto M
P2860
P304
10056-10062
P356
10.1074/JBC.M010188200
P407
P577
2000-12-27T00:00:00Z