Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.
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Insertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities.Selection of primer-template sequences that bind human immunodeficiency virus reverse transcriptase with high affinityMechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinesStructural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptaseStructures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistancePolycitone A, a novel and potent general inhibitor of retroviral reverse transcriptases and cellular DNA polymerasesMechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTPSelective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexesUnblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanismMode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerasesRegulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionKinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Duplex structural differences and not 2'-hydroxyls explain the more stable binding of HIV-reverse transcriptase to RNA-DNA versus DNA-DNA.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Significant contribution of the 3'→5' exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ.A primer-free method that selects high-affinity single-stranded DNA aptamers using thermostable RNA ligase.A cell-based strategy to assess intrinsic inhibition efficiencies of HIV-1 reverse transcriptase inhibitors.Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionThe exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sitesComparison of the kinetic parameters of the truncated catalytic subunit and holoenzyme of human DNA polymerase ɛ.Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.DNA aptamers to human immunodeficiency virus reverse transcriptase selected by a primer-free SELEX method: characterization and comparison with other aptamers.Human immunodeficiency virus-1 reverse transcriptase heterodimer stability.Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.Biochemical mechanism of HIV-1 resistance to rilpivirine.Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analysesSelection of 2'-deoxy-2'-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinityBinding of RNA template to a complex of HIV-1 reverse transcriptase/primer/templateMechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase.Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+.Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+.Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds.Dynamic binding orientations direct activity of HIV reverse transcriptaseKinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases.
P2860
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P2860
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@en
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@nl
type
label
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@en
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@nl
prefLabel
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@en
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@nl
P2093
P1476
Kinetic mechanism of the DNA-d ...... y virus reverse transcriptase.
@en
P2093
P304
24607-24613
P407
P577
1993-11-01T00:00:00Z