Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

Item
http://www.wikidata.org/entity/Q28343830
The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kineticsMechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosineNucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase.Novel use of a guanosine prodrug approach to convert 2',3'-didehydro-2',3'-dideoxyguanosine into a viable antiviral agentProbing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphateReduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophageDifferential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates.North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity.Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs.Reverse transcriptase mutations in HIV-1 infected patients treated with two nucleoside analogues: the SMART study.
P2860

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

Item
http://www.wikidata.org/entity/Q28343830
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mechanism of inhibition of the ...... to the natural substrate dTTP
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Mechanism of inhibition of the ...... to the natural substrate dTTP
@en
Mechanism of inhibition of the ...... to the natural substrate dTTP
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type
label
Mechanism of inhibition of the ...... to the natural substrate dTTP
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Mechanism of inhibition of the ...... to the natural substrate dTTP
@en
Mechanism of inhibition of the ...... to the natural substrate dTTP
@nl
prefLabel
Mechanism of inhibition of the ...... to the natural substrate dTTP
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Mechanism of inhibition of the ...... to the natural substrate dTTP
@en
Mechanism of inhibition of the ...... to the natural substrate dTTP
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Mechanism of inhibition of the ...... to the natural substrate dTTP
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P2093
P2860
P304
P31
P356
10.1128/AAC.44.1.217-221.2000
P407
P433
P478
P577
P5875
P698
P932