Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer.
about
The Lutheran glycoprotein: a multifunctional adhesion receptorTolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityLIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation.AAV's anatomy: roadmap for optimizing vectors for translational successHepatic gene transfer as a means of tolerance induction to transgene productsBALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsCell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.RETRACTED: Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapyDevelopment of Gene Transfer for Induction of Antigen-specific Tolerance.Intrinsic transgene immunogenicity gears CD8(+) T-cell priming after rAAV-mediated muscle gene transfer.Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.Systemic protein delivery by muscle-gene transfer is limited by a local immune response.Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer.Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivoModulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver.Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.Cytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice.Tolerance induction by viral in vivo gene transferGene therapy for treatment of inherited haematological disorders.Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease.Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector.Gene therapy progress and prospects: the skin--easily accessible, but still far away.Cellular and molecular mechanisms of liver tolerance.Evading the immune response upon in vivo gene therapy with viral vectors.Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes.Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance.Immune responses to AAV vectors: overcoming barriers to successful gene therapyLong-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.Immunity to adeno-associated virus vectors in animals and humans: a continued challenge.Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant miceEffective gene therapy for haemophilic mice with pathogenic factor IX antibodies.AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cellsThe role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transferThe companions: regulatory T cells and gene therapy.Role of regulatory T cells in tolerance to coagulation factors.AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.The complex and evolving story of T cell activation to AAV vector-encoded transgene products.In vivo induction of regulatory T cells for immune tolerance in hemophilia.
P2860
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P2860
Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Induction of antigen-specific ...... y in vivo viral gene transfer.
@en
Induction of antigen-specific ...... y in vivo viral gene transfer.
@nl
type
label
Induction of antigen-specific ...... y in vivo viral gene transfer.
@en
Induction of antigen-specific ...... y in vivo viral gene transfer.
@nl
prefLabel
Induction of antigen-specific ...... y in vivo viral gene transfer.
@en
Induction of antigen-specific ...... y in vivo viral gene transfer.
@nl
P2093
P1433
P1476
Induction of antigen-specific ...... y in vivo viral gene transfer.
@en
P2093
Elisabeth Bendo
Eric Dobrzynski
Federico Mingozzi
Lixin Wang
Roland W Herzog
Yi-Lin Liu
P304
P356
10.1182/BLOOD-2004-03-0847
P407
P577
2004-04-22T00:00:00Z