Common inhibitory effects of human anti-C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor.
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Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopesPreparation of anhydrothrombin and characterization of its interaction with natural thrombin substratesNon-classical anti-factor VIII C2 domain antibodies are pathogenic in a murine in vivo bleeding model.Immune tolerance induction: recombinant vs. human-derived product.The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfacesAntihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies.Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibodySpecific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.Successful immune tolerance induction with factor VIII/von Willebrand factor concentrate in an elderly patient with severe haemophilia A and a high responder inhibitorDiscontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer-designed synthetic peptides.von Willebrand factor in factor VIII concentrates protects against neutralization by factor VIII antibodies of haemophilia A patients.Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities.Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition.Use of Haemate(®) P as immune tolerance induction in patients with severe haemophilia A who failed previous induction attempts: a multicentre observational study.Characterization of inhibitors to FVIII with an ELISA in congenital and acquired haemophilia A.The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex.Kinetic parameters of monoclonal antibodies ESH2, ESH4, ESH5, and ESH8 on coagulation factor VIII and their influence on factor VIII activity.An intronic mutation c.6430-3C>G in the F8 gene causes splicing efficiency and premature termination in hemophilia A.Molecular Characterization of the Immune Response to Factor VIII
P2860
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P2860
Common inhibitory effects of human anti-C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Common inhibitory effects of h ...... ding to von Willebrand factor.
@en
Common inhibitory effects of h ...... ding to von Willebrand factor.
@nl
type
label
Common inhibitory effects of h ...... ding to von Willebrand factor.
@en
Common inhibitory effects of h ...... ding to von Willebrand factor.
@nl
prefLabel
Common inhibitory effects of h ...... ding to von Willebrand factor.
@en
Common inhibitory effects of h ...... ding to von Willebrand factor.
@nl
P2093
P2860
P1476
Common inhibitory effects of h ...... ding to von Willebrand factor.
@en
P2093
Morichika S
Murakami T
Sawamoto Y
Scandella D
Yoshioka A
P2860
P304
P356
10.1111/J.1365-2141.1995.TB05374.X
P407
P577
1995-11-01T00:00:00Z