Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.
about
ZW10 links mitotic checkpoint signaling to the structural kinetochore.Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceSilencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death.The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossBubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayA mitotic septin scaffold required for Mammalian chromosome congression and segregationLinking kinetochore-microtubule binding to the spindle checkpointWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsStructural analysis of Bub3 interactions in the mitotic spindle checkpointHistone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts.Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Structural and mechanistic insights into Mps1 kinase activationDefining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 InhibitionMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointKinetochore localization of spindle checkpoint proteins: who controls whom?Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance.The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation.Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.BubR1 is modified by sumoylation during mitotic progressionSumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progressionLoss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresCenp-meta is required for sustained spindle checkpointSUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochoresSeparating the spindle, checkpoint, and timer functions of BubR1Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyTranscriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.The kinetochoreKinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.The spindle checkpoint, aneuploidy, and cancer.Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progressionThe dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation
P2860
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P2860
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Activating and silencing the m ...... ivation/inactivation of BubR1.
@en
Activating and silencing the m ...... ivation/inactivation of BubR1.
@nl
type
label
Activating and silencing the m ...... ivation/inactivation of BubR1.
@en
Activating and silencing the m ...... ivation/inactivation of BubR1.
@nl
prefLabel
Activating and silencing the m ...... ivation/inactivation of BubR1.
@en
Activating and silencing the m ...... ivation/inactivation of BubR1.
@nl
P2093
P50
P1433
P1476
Activating and silencing the m ...... tivation/inactivation of BubR1
@en
P2093
Ariane Abrieu
Don W Cleveland
Yinghui Mao
P356
10.1016/S0092-8674(03)00475-6
P407
P577
2003-07-01T00:00:00Z