Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. - Wikidata - wikimedia - TriplyDB

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.

http://www.wikidata.org/entity/Q45960821

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Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis The Akt-associated microRNAs Noncoding RNAs in DNA repair and genome integrity Tumor suppressor microRNAs: a novel non-coding alliance against cancer TP53/MicroRNA Interplay in Hepatocellular Carcinoma NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction.SRF is required for neutrophil migration in response to inflammation.Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer.microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways.microRNA expression and biogenesis in cellular response to ionizing radiation MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor Cholesterol-conjugated let-7a mimics: antitumor efficacy on hepatocellular carcinoma in vitro and in a preclinical orthotopic xenograft model of systemic therapy Cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells via the Rho signaling pathway MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression.MicroRNAs are part of the regulatory network that controls EGF induced apoptosis, including elements of the JAK/STAT pathway, in A431 cells.Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction miR-34 and p53: New Insights into a Complex Functional Relationship.Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis.Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome.The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma.The impact of post-transcriptional regulation in the p53 network.miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells Epigenetic silencing of miR-145-5p contributes to brain metastasis TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis.microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells.The MDM2-p53 pathway revisited The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells.Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.MiR-320a inhibits gastric carcinoma by targeting activity in the FoxM1-P27KIP1 axis.Functions of microRNA-143 in the apoptosis, invasion and migration of nasopharyngeal carcinoma

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Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.

http://www.wikidata.org/entity/Q45960821

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

@en

Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

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type

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Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

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Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

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prefLabel

Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

@en

Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

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Loss of microRNA-143/145 distu ...... ng the MDM2-p53 feedback loop.

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Hallmarks of Cancer: The Next Generation

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network

miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer

Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene

p53 represses c-Myc through induction of the tumor suppressor miR-145

MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

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10.1038/ONC.2012.28

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1005461953

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