Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
about
Explaining oscillations and variability in the p53-Mdm2 systemPhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseRegulation of p53 stability and function by the deubiquitinating enzyme USP42Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loopMdmX is a substrate for the deubiquitinating enzyme USP2aTrim24 targets endogenous p53 for degradationDeregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targetsDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transUbp2 regulates Rsp5 ubiquitination activity in vivo and in vitro.Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation.Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageIdentification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin DModes of p53 regulationTherapeutic considerations for Mdm2: not just a one trick ponyStress-specific response of the p53-Mdm2 feedback loopThe regulation of the p53-mediated stress response by MDM2 and MDM4.Mdm proteins: critical regulators of embry ogenesis and homeostasis.Autoantibody response to murine double minute 2 protein in immunodiagnosis of hepatocellular carcinoma.Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.MDM2 oligomers: antagonizers of the guardian of the genome.The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.The p53 orchestra: Mdm2 and Mdmx set the toneRole of Pirh2 in mediating the regulation of p53 and c-Myc.MDM2, MDMX and p53 in oncogenesis and cancer therapyRibosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisThe impact of acetylation and deacetylation on the p53 pathway.Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.p53 post-translational modification: deregulated in tumorigenesisLimiting the power of p53 through the ubiquitin proteasome pathway.Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapyMGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4Making sense of ubiquitin ligases that regulate p53.New insights into p53 activationMdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.
P2860
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P2860
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
description
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Oktober 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/10/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/10/01)
@nl
наукова стаття, опублікована в жовтні 2007
@uk
مقالة علمية (نشرت في أكتوبر 2007)
@ar
name
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@ast
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@en
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@nl
type
label
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@ast
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@en
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@nl
prefLabel
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@ast
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@en
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@nl
P2093
P921
P1433
P1476
Targeted inactivation of Mdm2 ...... c insights into p53 regulation
@en
P2093
Gerard I. Evan
Hilary V. Clegg
Krishna P. Bhat
Mikael S. Lindström
Virginia L. Godfrey
Yanping Zhang
Yoko Itahana
P304
P356
10.1016/J.CCR.2007.09.007
P50
P577
2007-10-01T00:00:00Z