Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.
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Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines.Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry.Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluationInhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury.The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.A systematic protocol for the characterization of Hsp90 modulators.Purine-scaffold Hsp90 inhibitors.Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma.Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential.Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.An update on the mouse liver proteome.Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated protein94 (Grp94)-IgG complexes.Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response.First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growth.
P2860
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P2860
Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@en
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@nl
type
label
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@en
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@nl
prefLabel
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@en
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@nl
P2093
P2860
P356
P1433
P1476
Targeting heat shock protein 9 ...... uman hepatocellular carcinoma.
@en
P2093
Benjamin Goeppert
Eloisi Caldas-Lopes
Frank Bergmann
Gabriela Chiosis
Marco Breinig
Michael André Kern
Peter Schirmacher
Ralf Rieker
P2860
P304
P356
10.1002/HEP.22912
P407
P577
2009-07-01T00:00:00Z