about
Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigeneticsThe role of histone demethylases in cancer therapyKDM1 class flavin-dependent protein lysine demethylasesRNA interference and heterochromatin assemblySynergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cellsLSD1 Histone Demethylase Assays and InhibitionH3K4 demethylase activities repress proliferative and postmitotic aging.Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression functionActivation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).Epigenetic regulation of androgen receptor signaling in prostate cancer.Epigenetic approaches to psychiatric disorders.MassSQUIRM: An assay for quantitative measurement of lysine demethylase activityUse of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.Epigenetic regulation of LSD1 during mammary carcinogenesis.LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMPThe interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cellsBacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones.H3K9 methyltransferase G9a and the related molecule GLP.Emerging roles of epigenetic mechanisms in Parkinson's disease.Epigenetic drug discovery: targeting DNA methyltransferases.Lysine methylation: beyond histones.LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.Advances toward LSD1 inhibitors for cancer therapy.Folate deficiency affects histone methylation.Insights into Jumonji C-domain containing protein 6 (JMJD6): a multifactorial role in foot-and-mouth disease virus replication in cells.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.Methylation-mediated regulation of E2F1 in DNA damage-induced cell death.The lasting influence of LSD1 in the blood.Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene.Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines.Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers.Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.Molecular signature of the imprintosome complex at the mating-type locus in fission yeast.Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
LSD1 demethylates histone and non-histone proteins.
@en
LSD1 demethylates histone and non-histone proteins.
@nl
type
label
LSD1 demethylates histone and non-histone proteins.
@en
LSD1 demethylates histone and non-histone proteins.
@nl
prefLabel
LSD1 demethylates histone and non-histone proteins.
@en
LSD1 demethylates histone and non-histone proteins.
@nl
P356
P1433
P1476
LSD1 demethylates histone and non-histone proteins.
@en
P2093
Taiping Chen
Thomas B Nicholson
P304
P356
10.4161/EPI.4.3.8443
P577
2009-04-14T00:00:00Z