about
IDH1 and IDH2 mutations in gliomasAscorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progressionMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateCancer metabolism: key players in metabolic reprogrammingIsocitrate dehydrogenase mutations: new opportunities for translational researchThe prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma.Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry.Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.Differential activity of NADPH-producing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma.Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice.Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.Inborn and acquired metabolic defects in cancer.Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H₂O₂--implications for their role in disease, especially cancer.Rare insights into cancer biology.Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.Enasidenib, a targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia.Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Cancer. Puzzling patterns of predisposition.
@en
Cancer. Puzzling patterns of predisposition.
@nl
type
label
Cancer. Puzzling patterns of predisposition.
@en
Cancer. Puzzling patterns of predisposition.
@nl
prefLabel
Cancer. Puzzling patterns of predisposition.
@en
Cancer. Puzzling patterns of predisposition.
@nl
P356
P1433
P1476
Cancer. Puzzling patterns of predisposition.
@en
P304
P356
10.1126/SCIENCE.1173362
P407
P577
2009-04-01T00:00:00Z