Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia.
about
Systemic VHL gene functions and the VHL diseaseZebrafish as an Emerging Model Organism to Study Angiogenesis in Development and RegenerationExploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish modelsHIF2a inhibitors for the treatment of VHL diseaseDevelopmental change in the function of movement systems: transition of the pectoral fins between respiratory and locomotor roles in zebrafishHaemodynamics-driven developmental pruning of brain vasculature in zebrafishHypoxia disruption of vertebrate CNS pathfinding through ephrinB2 Is rescued by magnesiumNitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish.Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose MetabolismMutations in LRRC50 predispose zebrafish and humans to seminomas.Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryoHif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish.Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney functionVHL, the story of a tumour suppressor gene.The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.Zebrafish as a model for normal and malignant hematopoiesis.The hypoxia signaling pathway and hypoxic adaptation in fishes.Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT PathwayPharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.Genome-wide mapping of Hif-1α binding sites in zebrafishComplex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Hooked! Modeling human disease in zebrafish.Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipidsVEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish.Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.Hypoxia as a therapy for mitochondrial disease.Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.Manipulation of the HIF-Vegf pathway rescues methyl tert-butyl ether (MTBE)-induced vascular lesions.HIF pathway mutations and erythrocytosis.Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and nonmalignant diseases.Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization.The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.Hypoxia-induced metastasis model in embryonic zebrafish.Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis.An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma.Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.
P2860
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P2860
Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@en
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@nl
type
label
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@en
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@nl
prefLabel
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@en
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@nl
P2093
P1433
P1476
Zebrafish mutants in the von H ...... pects of Chuvash polycythemia.
@en
P2093
Ellen van Rooijen
Emile E Voest
Fredericus J van Eeden
Ive Logister
Jeroen Korving
Rachel H Giles
Stefan Schulte-Merker
Thorsten Schwerte
P304
P356
10.1182/BLOOD-2008-07-167890
P407
P577
2009-03-20T00:00:00Z