AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.
about
C/EBPα Dysregulation in AML and ALLAcute Myeloid Leukemia: A Concise ReviewMolecular landscape of acute myeloid leukemia in younger adults and its clinical relevanceMolecular prognostic factors in cytogenetically normal acute myeloid leukemiaRUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome.RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.Novel Prognostic and Therapeutic Mutations in Acute Myeloid LeukemiaTargeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and TreatmentSignificance of oncogenes and tumor suppressor genes in AML prognosis.Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP).Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemiaTdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia.The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Gene mutation patterns in patients with minimally differentiated acute myeloid leukemia.RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Hierarchical cluster analysis of immunophenotype classify AML patients with NPM1 gene mutation into two groups with distinct prognosisThe N-terminal CEBPA mutant in acute myeloid leukemia impairs CXCR4 expressionRunx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia.Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adultsSomatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemiaRunx1 loss minimally impacts long-term hematopoietic stem cellsRUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingDistinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia.Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid LeukemiaDownregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice.TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution.A Modified Integrated Genetic Model for Risk Prediction in Younger Patients with Acute Myeloid Leukemia.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification.Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors GranulopoiesisHigher expression levels of the HOXA9 gene, closely associated with MLL-PTD and EZH2 mutations, predict inferior outcome in acute myeloid leukemia.RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia.
P2860
Q22065117-449959C5-4704-4196-BF58-723B97587EC1Q26766719-1F639301-7037-49E6-9CAF-C460247923F8Q26776393-B8F7A5A5-915D-483F-A0D0-38C10EA7E231Q26998811-7047E2B1-2150-490C-86BE-7AD64423FA7FQ27851839-0C72DF72-D4DD-451D-876C-A7CC02A77700Q27851909-8410E42E-A164-435D-BACA-CA3CC623D4B3Q27853381-C21EBDD3-2D79-45F4-8DA0-B3AE4C6EE427Q28075654-D5187B3E-67A0-4879-9CD8-F3CF08C467ADQ28076462-0B6E9DB5-F4D1-4F33-9173-4743571C1708Q30250315-0377DA95-7265-4486-B75F-789DBECC55B6Q33419236-0C646612-967C-46A6-A39D-54F802D836A5Q33573503-19C9BE79-9DDF-4194-AF29-EAEFACD069E2Q33737486-137A7FA3-4DF3-43A2-9280-A48465DCC00DQ33746724-97142044-3E21-4EBB-8DB8-E8CE1F49B27EQ33836390-12211A64-36EE-4BDD-9175-9788865B8B79Q33919296-C218376C-06F6-4E57-8E7C-C88F4CD02AD1Q34318485-F864DFB0-0077-4F3F-8717-3F4963400AFDQ34347096-1B8D01FF-9107-42E2-9D86-3D1852D0E987Q34621037-D09EC3FB-F3B2-4EFE-B367-226A03C062EDQ34621996-EE73541F-F2A6-4361-A88B-ACA73DDB4FD1Q34649120-BCB0BAC8-08B2-4864-AF1E-A8ED3B57B50BQ34852828-A4C78644-910C-4528-B936-60571CE81F84Q35018755-F318F541-B722-458C-905D-287B8823ED88Q35203340-FE991793-EE70-4017-936E-F429ABC98741Q35568696-DA6276C0-53D6-4DDA-948A-E518DC5FF756Q35585976-0DE802E4-8CCD-48F2-8D4E-AD5743A1D253Q35586823-607DA6C6-FC3C-4C66-AA82-C8F43A21FD86Q35642451-727B0264-EEC8-49BC-999C-81E152915F8CQ35653963-6894435C-80F5-4F64-B127-E72F2138C954Q35692708-76FE505E-7AA7-42C8-B54B-0BC084E4BE42Q35724527-DA6C437F-C1C7-4759-AAF6-5E22C2306397Q35920680-A1AFB6F1-99DF-45F2-A1DC-FCD70D90BD18Q35921904-2B358D56-F971-4E50-9E42-0FC0BE88ECA2Q35981082-2F0DDA09-330B-451A-B9CD-01CE94B9DD65Q35995201-DDFEAD3C-42F3-4902-A25A-D805FD4267C3Q36366616-B837B375-05DA-4CA2-A12B-1F51D8FB9F14Q36442414-C5DF3151-DF55-48DC-AB3A-08020D62641EQ36585150-9EF42A64-F195-40B7-8D81-D4B026F3D395Q36662047-C156DD0E-C926-4950-84A2-A56FEB288ABFQ36842838-702AAADA-889B-4954-9781-76068ACB3300
P2860
AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@en
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@nl
type
label
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@en
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@nl
prefLabel
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@en
AML1/RUNX1 mutations in 470 ad ...... n with other gene alterations.
@nl
P2093
P50
P1433
P1476
AML1/RUNX1 mutations in 470 ad ...... on with other gene alterations
@en
P2093
Chi-Fei Huang
Chieh-Yu Liu
Chien-Yuan Chen
Fen-Yu Lee
Mei-Hsuan Tseng
Ming-Chih Liu
Shang-Ju Wu
Shang-Yi Huang
Szu-Chun Hsu
P304
P356
10.1182/BLOOD-2009-05-223784
P407
P577
2009-10-06T00:00:00Z