TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.
about
Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channelsVariomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A.A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calciumAnoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.TMEM16 chloride channels are two-faced.Cl⁻ channels in smooth muscle cells.TMEM16 proteins: unknown structure and confusing functions.Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.New Insights on the Regulation of Ca2+ -Activated Chloride Channel TMEM16A.Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism.Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel.Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.Intermolecular Interactions in the TMEM16A Dimer Controlling Channel ActivityCryo-EM structures of the TMEM16A calcium-activated chloride channel.TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl- currentand regulate melatonin secretion in rat pineal glands.Anion permeation in calcium-activated chloride channels formed by TMEM16A from Xenopus tropicalis.Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells.Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.
P2860
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P2860
TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.
description
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name
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@en
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@nl
type
label
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@en
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@nl
prefLabel
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@en
TMEM16A-TMEM16B chimaeras to i ...... m-activated chloride channels.
@nl
P50
P356
P1433
P1476
TMEM16A-TMEM16B chimaeras to i ...... um-activated chloride channels
@en
P2093
Emanuela Caci
Roberto Ravazzolo
P304
P356
10.1042/BJ20130348
P407
P577
2013-06-01T00:00:00Z