Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linkingALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear importInside out: the role of nucleocytoplasmic transport in ALS and FTLDThe extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivoImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationAlterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseCalcium dysregulation links ALS defective proteins and motor neuron selective vulnerabilityTar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissueAnalysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosisTDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.High-Resolution RNA Maps Suggest Common Principles of Splicing and Polyadenylation Regulation by TDP-43.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentC-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stressAmyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.Compensatory Motor Neuron Response to Chromatolysis in the Murine hSOD1(G93A) Model of Amyotrophic Lateral SclerosisFutsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.Targeting RNA binding proteins involved in neurodegeneration.A fruitful endeavor: modeling ALS in the fruit flyIdentification of testis 14-3-3 binding proteins by tandem affinity purificationGains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.From Transcriptome to Noncoding RNAs: Implications in ALS Mechanism.TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.Quantitative Proteomic Analysis of the Response to Zinc, Magnesium, and Calcium Deficiency in Specific Cell Types of Arabidopsis Roots.The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis.Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels.Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients.RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.
P2860
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P2860
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@en
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@nl
type
label
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@en
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@nl
prefLabel
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@en
Tar DNA binding protein of 43 ...... ophic lateral sclerosis (ALS).
@nl
P2093
P1433
P1476
Tar DNA binding protein of 43 ...... rophic lateral sclerosis (ALS)
@en
P2093
Cheryl Leystra-Lantz
Howard Jaffee
Kathryn Volkening
Wenchang Yang
P304
P356
10.1016/J.BRAINRES.2009.09.105
P407
P577
2009-10-06T00:00:00Z