Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
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Nitric oxide synthases in heart failureStructural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthaseBeta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzymeDirect calcium binding results in activation of brain serine racemaseSubunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoformsCharacterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerizationEndothelial nitric oxide synthase in the microcirculation.Regulation of obesity and insulin resistance by nitric oxideMutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis.Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia.Reconstitution of pterin-free inducible nitric-oxide synthase.Tetrahydrobiopterin in cardiovascular health and disease.Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibitionTetrahydrobiopterin, superoxide, and vascular dysfunction.Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase.Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production.Endothelial nitric oxide in humans in health and disease.The autoinhibitory control element and calmodulin conspire to provide physiological modulation of endothelial and neuronal nitric oxide synthase activity.Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption.Protein engineering to develop a redox insensitive endothelial nitric oxide synthaseEnterohemorrhagic Escherichia coli O157: epidemiology and ecology in bovine production environments.Antiobesogenic role of endothelial nitric oxide synthase.The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity.Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase.Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.eNOS uncoupling and endothelial dysfunction in aged vessels.Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase.Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.Endothelial dysfunction and hypertension in aging.Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis.Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.
P2860
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P2860
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@en
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@nl
type
label
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@en
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@nl
prefLabel
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@en
Endothelial nitric-oxide synth ...... obiopterin in dimer formation.
@nl
P2860
P356
P1476
Endothelial nitric-oxide synth ...... robiopterin in dimer formation
@en
P2093
N C Gerber
P R Ortiz de Montellano
P2860
P304
11462-11467
P356
10.1074/JBC.271.19.11462
P407
P577
1996-05-01T00:00:00Z