Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.
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De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1Mapping autism risk loci using genetic linkage and chromosomal rearrangements.N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylationCa2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttleContribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neuronsMolecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartiaGlucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat.Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation.Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disordersPyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disordersTranscriptional regulation of N-acetylaspartate metabolism in the 5xFAD model of Alzheimer's disease: evidence for neuron-glia communication during energetic crisis.Association between genetic variants in SLC25A12 and risk of autism spectrum disorders: An integrated meta-analysis.Altered postnatal development of cortico-hippocampal neuronal electric activity in mice deficient for the mitochondrial aspartate-glutamate transporter.Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.Mitochondrial transporters as novel targets for intracellular calcium signaling.Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse RetinaA Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by (1)H NMR-Based Metabonomics and the NF-κB Pathway.Cytosolic reducing power preserves glutamate in retina.Deficient glucose and glutamine metabolism in Aralar/AGC1/Slc25a12 knockout mice contributes to altered visual functionInhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retinaStructure and function of mitochondrial carriers - role of the transmembrane helix P and G residues in the gating and transport mechanism.The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autism.Mitochondrial Aspartate/Glutamate Carrier SLC25A12 and Autism Spectrum Disorder: a Meta-Analysis.Brain glutaminases.Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism.Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism.The mitochondrial aspartate/glutamate carrier isoform 1 gene expression is regulated by CREB in neuronal cells.Phenotype-Dependent Interactions between N-acetyl-L-Aspartate and Acetyl-CoA in Septal SN56 Cholinergic Cells Exposed to an Excess of Zinc.Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.Mass spectrometrical analysis of the mitochondrial carrier Aralar1 from mouse hippocampus.Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry.Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.Low levels of citrin (SLC25A13) expression in adult mouse brain restricted to neuronal clusters.Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.
P2860
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P2860
Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@en
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@nl
type
label
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@en
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@nl
prefLabel
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@en
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@nl
P2093
P2860
P356
P1476
Reduced N-acetylaspartate leve ...... l aspartate-glutamate carrier.
@en
P2093
Akiko Okubo
Beatriz Pardo
Jorgina Satrústegui
Keiko Kobayashi
Kyoko Shimotsu
Laila Begum
Masahisa Horiuchi
Md Abdul Jalil
Meng Xian Li
Mikio Iijima
P2860
P304
31333-31339
P356
10.1074/JBC.M505286200
P407
P577
2005-06-29T00:00:00Z