Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction.
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Strategies for treatment in Alexander diseaseAlexander diseaseGFAP and its role in Alexander diseaseDysfunctions of neuronal and glial intermediate filaments in diseaseHerpesviruses and intermediate filaments: close encounters with the third typeGenetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survivalAstrocyte heterogeneity in the brain: from development to diseaseTh2 skewing by activation of Nrf2 in CD4(+) T cellsDrug screening to identify suppressors of GFAP expressionOligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP.Connectivity of default-mode network is associated with cerebral edema in hepatic encephalopathyProtein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease modelLithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytesCSF and Blood Levels of GFAP in Alexander DiseaseProtection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb 761 involving glial fibrillary acidic proteinBeneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.Protein changes in immunodepleted cerebrospinal fluid from a transgenic mouse model of Alexander disease detected using mass spectrometryGFAP expression as an indicator of disease severity in mouse models of Alexander disease.Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander diseaseComposition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseThe role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP.ASTROCYTES: EMERGING STARS IN LEUKODYSTROPHY PATHOGENESIS.Astrocyte pathology in Alexander disease causes a marked inflammatory environment.HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation.Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease.Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain.Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature OligodendrocytesProperties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.Effects of a polymorphism in the GFAP promoter on the age of onset and ambulatory disability in late-onset Alexander disease.Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease.Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.Metabolic etiologies in West syndrome.
P2860
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P2860
Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@en
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@nl
type
label
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@en
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@nl
prefLabel
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@en
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@nl
P2093
P2860
P356
P1476
Gene expression analysis in mi ...... tion and neuronal dysfunction.
@en
P2093
Albee Messing
Delinda A Johnson
Jeffrey A Johnson
Mark A Smith
Stephen A Gaeta
Tracy L Hagemann
P2860
P304
P356
10.1093/HMG/DDI248
P577
2005-07-13T00:00:00Z