Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity. - Wikidata - wikimedia - TriplyDB

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity.

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity.

http://www.wikidata.org/entity/Q46644000

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Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition Decoding the Matrix: Instructive Roles of Proteoglycan Receptors Review collagen-based biomaterials for wound healing Glycoconjugates and related molecules in human vascular endothelial cells Pivotal role for decorin in angiogenesis Decorin mimic regulates platelet-derived growth factor and interferon-γ stimulation of vascular smooth muscle cells Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness Decorin differentially modulates the activity of insulin receptor isoform A ligands.Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology Vascular accumulation of the small leucine-rich proteoglycan decorin in CADASIL.Soluble biglycan as a biomarker of inflammatory renal diseases.Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival.Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice.The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis Decorin mimic inhibits vascular smooth muscle proliferation and migration.Allosteric regulation of pathologic angiogenesis: potential application for angiogenesis-related blindness.Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.Decorin-TGFβ axis in hepatic fibrosis and cirrhosis Decorin: a guardian from the matrix Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.Dichotomy of decorin activity on the insulin-like growth factor-I system Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorin.Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.Biological functions of decorin in cancer.Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice.Molecular interplay between endostatin, integrins, and heparan sulfate.ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro.Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling.Decorin in atherosclerosis.Molecular Functions of Glycoconjugates in Autophagy.Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification.Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast The integrin needle in the stromal haystack: emerging role in corneal physiology and pathology.The role for decorin in delayed-type hypersensitivity Decorin regulates endothelial cell-matrix interactions during angiogenesis.The matricellular functions of small leucine-rich proteoglycans (SLRPs).

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P2860

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity.

http://www.wikidata.org/entity/Q46644000

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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name

Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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type

label

Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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prefLabel

Decorin regulates endothelial ...... alpha2beta1 integrin activity.

@en

Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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P1433

Journal of Biological Chemistry

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Decorin regulates endothelial ...... alpha2beta1 integrin activity.

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P2093

Daniela G Seidler

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Elke Schönherr

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Johannes A Eble

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Rachel Waddington

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Stephan Niland

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P2860

Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues

Structural basis of collagen recognition by integrin alpha2beta1

alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD-independent disintegrin and potent inhibitor of cell adhesion to collagen.

Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration.

Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.

Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases.

Decorin is produced by capillary endothelial cells in inflammation-associated angiogenesis.

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs.

Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility.

Integrin structure, allostery, and bidirectional signaling.

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17406-17415

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scholarly article

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10.1074/JBC.M710025200

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25

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283

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Daniel Aeschlimann

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2008-04-14T00:00:00Z

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18413316

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