Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).
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Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptorsConserved MIP receptor-ligand pair regulates Platynereis larval settlementComparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.Atherogenic dyslipidemia and combination pharmacotherapy in diabetes: recent clinical trials.Future of GPR109A agonists in the treatment of dyslipidaemia.Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.Atheroprotective lipoprotein effects of a niacin-simvastatin combination compared to low- and high-dose simvastatin monotherapy.Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parametersThe atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signalingBiological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in bilaterians.Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.Nicotinic acid: an old drug with a promising futureBidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidismNiacin: a re-emerging pharmaceutical for the treatment of dyslipidaemia.Novel patent publications on high-affinity nicotinic acid receptor agonists.Acyl hydroxypyrazoles as novel agonists for high-affinity nicotinic acid receptor GPR109A: WO2008051403.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease.Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonistsDistinct kinetic and spatial patterns of protein kinase C (PKC)- and epidermal growth factor receptor (EGFR)-dependent activation of extracellular signal-regulated kinases 1 and 2 by human nicotinic acid receptor GPR109A.The Pharmacology and Function of Receptors for Short-Chain Fatty Acids.Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy.A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling.Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84.Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.Cloning and characterization of the hamster and guinea pig nicotinic acid receptors.
P2860
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P2860
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Characterization of determinan ...... ceptor GPR109A (HM74A/PUMA-G).
@en
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A
@nl
type
label
Characterization of determinan ...... ceptor GPR109A (HM74A/PUMA-G).
@en
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A
@nl
prefLabel
Characterization of determinan ...... ceptor GPR109A (HM74A/PUMA-G).
@en
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A
@nl
P50
P356
P1476
Characterization of determinan ...... ceptor GPR109A (HM74A/PUMA-G).
@en
P2093
Gerd Krause
Jens Lättig
P304
P356
10.1124/MOL.105.015750
P577
2005-08-11T00:00:00Z