Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.
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Experimental models of hepatotoxicity related to acute liver failureIntegrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochipAMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and FunctionHemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitroAcute exposure to ozone exacerbates acetaminophen-induced liver injury in miceAcetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.Zebrafish as model organisms for studying drug-induced liver injuryTreatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genesAcetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture modelAcetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.Organotypic systems in drug metabolism and toxicity: challenges and opportunities.Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.Early activated hepatic stellate cell-derived paracrine molecules modulate acute liver injury and regeneration.The Brassica epithionitrile 1-cyano-2,3-epithiopropane triggers cell death in human liver cancer cells in vitro.Antiproliferative and apoptotic activities of extracts of Asclepias subulata.Intestinal glucose uptake protects liver from lipopolysaccharide and D-galactosamine, acetaminophen, and alpha-amanitin in mice.Acetaminophen toxicity in rat and mouse hepatocytes in vitro.A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing.Inter-Individual Variability in Acute Toxicity of R-Pulegone and R-Menthofuran in Human Liver Slices and Their Influence on miRNA Expression Changes in Comparison to Acetaminophen.
P2860
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P2860
Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Interspecies differences in ac ...... and mouse primary hepatocytes.
@en
Interspecies differences in ac ...... and mouse primary hepatocytes.
@nl
type
label
Interspecies differences in ac ...... and mouse primary hepatocytes.
@en
Interspecies differences in ac ...... and mouse primary hepatocytes.
@nl
prefLabel
Interspecies differences in ac ...... and mouse primary hepatocytes.
@en
Interspecies differences in ac ...... and mouse primary hepatocytes.
@nl
P2093
P1433
P1476
Interspecies differences in ac ...... and mouse primary hepatocytes.
@en
P2093
Katalin Monostory
László Kóbori
László Vereczkey
Zsuzsa Veres
P304
P356
10.1016/J.TIV.2008.02.001
P577
2008-02-13T00:00:00Z