Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.
about
Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide IsosteresA test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trialsLGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation.Protein tyrosine phosphatases as potential therapeutic targets.6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.Targeting protein tyrosine phosphatases for anticancer drug discovery.Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cellsA quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light.CDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors.New combination therapies with cell-cycle agentsCDC25 phosphatases in cancer cells: key players? Good targets?PRL-3: a metastasis-associated phosphatase in search of a function.Is Cdc25 a druggable target?Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review.Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death.G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components.Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells.New Approaches to Difficult Drug Targets: The Phosphatase Story
P2860
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P2860
Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.
description
2005 nî lūn-bûn
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2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
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2005年學術文章
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2005年學術文章
@zh-hant
name
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@en
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@nl
type
label
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@en
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@nl
prefLabel
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@en
Inhibition of human tumor cell ...... hibitor of CDC25 phosphatases.
@nl
P2093
P1476
Inhibition of human tumor cell ...... nhibitor of CDC25 phosphatases
@en
P2093
Gregoire P Prevost
Marie-Christine Brezak
Marie-Odile Contour-Galcera
Muriel Quaranta
Odile Mondesert
Philip G Kasprzyk
Pierrïck Auvray
P304
P356
10.1158/1535-7163.MCT-05-0168
P577
2005-09-01T00:00:00Z