Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
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NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signalingHow animal models of leukaemias have already benefited patientsModulators of the structural dynamics of the retinoid X receptor to reveal receptor functionA coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promotersCell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.cFos mediates cAMP-dependent generation of ROS and rescue of maturation program in retinoid-resistant acute promyelocytic leukemia cell line NB4-LR1.Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messengerTributyltin differentially promotes development of a phenotypically distinct adipocyteTargeting truncated RXRα for cancer therapy.8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.Retinoids and rexinoids in cancer prevention: from laboratory to clinic.Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies.Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.Effects of LG268 on Cell Proliferation and Apoptosis of NB4 CellsRXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent mannerTowards novel paradigms for cancer therapy.Retinoids: novel immunomodulators and tumour-suppressive agents?Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.Induced differentiation of acute myeloid leukemia cells by activation of retinoid X and liver X receptors.Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD.Survival improvement of poor-prognosis AML/MDS patients by maintenance treatment with low-dose chemotherapy and differentiating agents.The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies.PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells nicheRXR, un cofacteur essentiel à la transformation dans les leucémies aiguës promyélocytaires
P2860
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P2860
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@en
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@nl
type
label
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@en
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@nl
prefLabel
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@en
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@nl
P2093
P50
P1433
P1476
Rexinoid-triggered differentia ...... nation of retinoid X receptor.
@en
P2093
Arthur Zelent
Aurélie Rossin
David Grimwade
Dominique Vitoux
Emmanuelle Wilhelm
Ettore Mariano Schiavone
Hugues de Thé
Mariacarla De Simone
Oliver Hirsch
P304
P356
10.1158/0008-5472.CAN-04-3569
P407
P577
2005-10-01T00:00:00Z