Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor. - Wikidata - wikimedia - TriplyDB

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.

http://www.wikidata.org/entity/Q46735203

about

NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling How animal models of leukaemias have already benefited patients Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.cFos mediates cAMP-dependent generation of ROS and rescue of maturation program in retinoid-resistant acute promyelocytic leukemia cell line NB4-LR1.Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger Tributyltin differentially promotes development of a phenotypically distinct adipocyte Targeting truncated RXRα for cancer therapy.8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.Retinoids and rexinoids in cancer prevention: from laboratory to clinic.Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies.Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.Effects of LG268 on Cell Proliferation and Apoptosis of NB4 Cells RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner Towards novel paradigms for cancer therapy.Retinoids: novel immunomodulators and tumour-suppressive agents?Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.Induced differentiation of acute myeloid leukemia cells by activation of retinoid X and liver X receptors.Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD.Survival improvement of poor-prognosis AML/MDS patients by maintenance treatment with low-dose chemotherapy and differentiating agents.The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies.PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche RXR, un cofacteur essentiel à la transformation dans les leucémies aiguës promyélocytaires

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P2860

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.

http://www.wikidata.org/entity/Q46735203

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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0008-5472.CAN-04-3569

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Cancer Research

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Rexinoid-triggered differentia ...... nation of retinoid X receptor.

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Arthur Zelent

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Aurélie Rossin

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David Grimwade

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Dominique Vitoux

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Emmanuelle Wilhelm

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Ettore Mariano Schiavone

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Hugues de Thé

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Mariacarla De Simone

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Oliver Hirsch

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8754-8765

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scholarly article

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10.1158/0008-5472.CAN-04-3569

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19

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65

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Hinrich Gronemeyer

Angela Nebbioso

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2005-10-01T00:00:00Z

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7561291

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16204045

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