about
The histone deacetylase 9 gene encodes multiple protein isoformsRegulation of Hoxb2 by APL-associated PLZF proteinAmino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion proteinPLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptorsColocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZFHistone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells.Acute promyelocytic leukemia: a paradigm for differentiation therapy.HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievementsDifferential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide.An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides.Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun.The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells.Retinoic acid inhibits the expression of cytidine deaminase linked to the differentiation of the human leukemic cell line HL-60.Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells.1 alpha,25-dihydroxyvitamin D3 transrepresses retinoic acid transcriptional activity via vitamin D receptor in myeloid cells.Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-reguRexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters.Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent.[Mechanism of action of retinoids in a new therapeutic approach to acute promyelocytic leukemia][Nuclear receptors and ontogenesis of the hematopoietic tissue]Hematopoietic growth factor expression and ATRA sensitivity in acute promyelocytic blast cellsPoor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patientRecruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoproteinSynthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor[Retrotransposons: selfish DNA or active epigenetic players in somatic cells?]
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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Fabien Guidez
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P106
P21
P31
P496
0000-0003-1380-4473