Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
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Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis.Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria.Purification, Characterization of L-Methioninase from Candida tropicalis, and Its Application as an Anticancer.De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.Targeting methionine auxotrophy in cancer: discovery & exploration.Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug.Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma.L-methionase: a therapeutic enzyme to treat malignancies.Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.Enzymatic assay for total plasma Cys.Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.Isolation of a homocysteine gamma-lyase-producing bacterium and study of its enzyme production conditions.Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chRecombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
P2860
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P2860
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Overexpression and large-scale ...... for novel anticancer therapy.
@en
Overexpression and large-scale ...... for novel anticancer therapy.
@nl
type
label
Overexpression and large-scale ...... for novel anticancer therapy.
@en
Overexpression and large-scale ...... for novel anticancer therapy.
@nl
prefLabel
Overexpression and large-scale ...... for novel anticancer therapy.
@en
Overexpression and large-scale ...... for novel anticancer therapy.
@nl
P2093
P356
P1476
Overexpression and large-scale ...... for novel anticancer therapy.
@en
P2093
Hoffman RM
Nagahama T
P304
P356
10.1006/PREP.1996.0700
P577
1997-03-01T00:00:00Z