Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

@en

Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

@en

Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

@nl

P1476

Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

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P2093

A Mayakonda

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D-C Lin

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E Baloglu

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E Park

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H P Koeffler

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M Lill

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M Müschen

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M Sudo

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S Gery

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S Takao

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P2860

Hallmarks of Cancer: The Next Generation

Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors.

Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

PAK signalling during the development and progression of cancer

IDH mutation impairs histone demethylation and results in a block to cell differentiation

THE METABOLISM OF TUMORS IN THE BODY

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.

P2888

leu.2017.281

P304

616-625

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P31

scholarly article

P356

10.1038/LEU.2017.281

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P433

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P478

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P577

2017-09-14T00:00:00Z

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P698

28904384

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P921

leukemia