Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.
about
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradationRedox control of glutamine utilization in cancerA human tRNA synthetase is a potent PARP1-activating effector target for resveratrolFunctional genomics platform for pooled screening and generation of mammalian genetic interaction maps.Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferaseDiscovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.The mTOR Complex Controls HIV Latency.Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B.Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.Novel methods and approaches to acute lymphoblastic leukemia drug discovery.Crystal structure-based comparison of two NAMPT inhibitors.NAD as a genotype-specific drug target.E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.NAMPT is the cellular target of STF-31-like small-molecule probes.Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells.Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes.CRISPR Approaches to Small Molecule Target Identification.SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.
P2860
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P2860
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@ast
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@en
type
label
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@ast
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@en
prefLabel
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@ast
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@en
P2093
P2860
P50
P1476
Next-generation NAMPT inhibito ...... nd functional genomic screens.
@en
P2093
Alicia J Donnelly
Christina J Matheny
Donna M Bouley
Masayuki Iwasaki
Michael C Bassik
Michael C Wei
Michael L Cleary
Obdulio Piloto
Patrick Brown
P2860
P304
P356
10.1016/J.CHEMBIOL.2013.09.014
P577
2013-10-31T00:00:00Z