Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway.
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Distinct initial SNARE configurations underlying the diversity of exocytosisExpression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoaADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Cell physiology of cAMP sensor Epac.Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channelsCa2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm.Signaling in sperm: toward a molecular understanding of the acquisition of sperm motility in the mouse epididymis.α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin.Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosisIdentification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.Central role of soluble adenylyl cyclase and cAMP in sperm physiology.Epac and PKA: a tale of two intracellular cAMP receptors.Guanine-nucleotide exchange factors (RAPGEF3/RAPGEF4) induce sperm membrane depolarization and acrosomal exocytosis in capacitated stallion sperm.Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa.Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosisChloride Is essential for capacitation and for the capacitation-associated increase in tyrosine phosphorylation.Compartmentalization of distinct cAMP signaling pathways in mammalian spermEpac activates the small G proteins Rap1 and Rab3A to achieve exocytosisEPAC proteins transduce diverse cellular actions of cAMP.Roles of intracellular cyclic AMP signal transduction in the capacitation and subsequent hyperactivation of mouse and boar spermatozoaNAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.The membrane of the mammalian spermatozoa: much more than an inert envelope.The proteins of exocytosis: lessons from the sperm model.The Molecules of Sperm Exocytosis.Amplification of FSH signaling by CFTR and nuclear soluble adenylyl cyclase in the ovary.Rap1 activation plays a regulatory role in pancreatic amylase secretion.The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells.Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis.GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis.Signaling pathways in ascidian oocyte maturation: the roles of cAMP/Epac, intracellular calcium levels, and calmodulin kinase in regulating GVBD.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
P2860
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P2860
Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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@zh-hans
2006年学术文章
@zh-my
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name
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@en
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@nl
type
label
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@en
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@nl
prefLabel
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@en
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@nl
P2093
P2860
P356
P1476
Calcium-induced acrosomal exoc ...... endent, Epac-mediated pathway.
@en
P2093
Claudia N Tomes
Luis S Mayorga
María T Branham
P2860
P304
P356
10.1074/JBC.M508854200
P407
P577
2006-01-10T00:00:00Z