Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.
about
Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic DiseasesMechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the TransloconAngiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes.Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes.Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.Estrogen attenuates AGTR1 expression to reduce pancreatic β-cell death from high glucose.Dipeptidyl peptidase-4 inhibitor sitagliptin improves pancreatic β-cell function in hypertensive diabetic patients treated with angiotensin receptor blockers.
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P2860
Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.
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name
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@en
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
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type
label
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@en
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@nl
prefLabel
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@en
Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@nl
P2093
P356
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Losartan, an angiotensin II ty ...... h the phospholipase C pathway.
@en
P2093
Anne-Marie Madec
Aurélia Mesnier
Charles Thivolet
Domenico Bosco
Fabien Van Coppenolle
Karim Chikh
Marie-Agnès Chauvin
Roméo Cassel
Sylvie Ducreux
Séverine Dubois
P304
P356
10.1096/FJ.13-234104
P407
P577
2013-09-05T00:00:00Z