Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
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Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysisStructures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate ComplexesInhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesStructural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparumAntimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate ReductoisomeraseTargeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of FosmidomycinKinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor.Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate ReductoisomeraseExpression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.Biochemistry of the non-mevalonate isoprenoid pathway.Targeting apicoplasts in malaria parasites.MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.NMR studies of DOXP reductoisomerase and its inhibitor complex.Targeting the nonmevalonate pathway in Burkholderia cenocepacia increases susceptibility to certain β-lactam antibiotics.The MEP pathway and the development of inhibitors as potential anti-infective agentsAryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum
P2860
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P2860
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
description
2006 nî lūn-bûn
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2006年学术文章
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2006年学术文章
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@zh-hant
name
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@en
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@nl
type
label
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@en
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@nl
prefLabel
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@en
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@nl
P2093
P1476
Synthesis of alpha-substituted ...... falciparum growth inhibitors.
@en
P2093
Dajana Henschker
Edwald Beck
Hassan Jomaa
Jan Goeman
Jochen Wiesner
Sara Van Poecke
Timothy Haemers
P304
P356
10.1016/J.BMCL.2005.12.082
P407
P577
2006-01-24T00:00:00Z