Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).
about
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyHdmx modulates the outcome of p53 activation in human tumor cellsEvolution of multiple cell clones over a 29-year period of a CLL patientIron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesisNGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation.Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.Targeting p53 by small molecules in hematological malignancies.Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor.Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21).Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2.Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cellsFunctional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival.Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomasExpression level of DEK in chronic lymphocytic leukemia is regulated by fludarabine and Nutlin-3 depending on p53 status.Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.Prognostic impact and targeting of CRM1 in acute myeloid leukemia.Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53.DNA damage response and development of targeted cancer treatments.The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma.Targeting the MDM2-p53 interaction for cancer therapyCyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AMLAn MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals.Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosisp53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies.Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia.Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations.Pharmacological activation of wild-type p53 in the therapy of leukemia.Induction of p53 suppresses chronic myeloid leukemia.Selective induction of TP53I3/p53-inducible gene 3 (PIG3) in myeloid leukemic cells, but not in normal cells, by Nutlin-3.SOCS1 is significantly up-regulated in Nutlin-3-treated p53wild-type B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155.Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
P2860
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P2860
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Functional integrity of the p5 ...... lymphocytic leukemia (B-CLL).
@en
Functional integrity of the p5 ...... l chronic lymphocytic leukemia
@nl
type
label
Functional integrity of the p5 ...... lymphocytic leukemia (B-CLL).
@en
Functional integrity of the p5 ...... l chronic lymphocytic leukemia
@nl
prefLabel
Functional integrity of the p5 ...... lymphocytic leukemia (B-CLL).
@en
Functional integrity of the p5 ...... l chronic lymphocytic leukemia
@nl
P2093
P50
P1433
P1476
Functional integrity of the p5 ...... lymphocytic leukemia (B-CLL).
@en
P2093
Antonio Cuneo
Carlotta Zerbinati
Elisa Barbarotto
Maria Grazia di Iasio
Renato Fanin
P304
P356
10.1182/BLOOD-2005-11-4465
P407
P577
2006-01-26T00:00:00Z