Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. - Wikidata - wikimedia - TriplyDB

Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.

Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.

http://www.wikidata.org/entity/Q33808489

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IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins The role of p53 in cancer drug resistance and targeted chemotherapy ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis Targeting p53 for Novel Anticancer Therapy.Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.Effect of glutathione combined with cisplatin and oxaliplatin on the proliferation and apoptosis of lung carcinoma cell line.MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity.MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival.hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis.Mitochondrial dysregulation and protection in cisplatin nephrotoxicity.mTOR contributes to ER stress and associated apoptosis in renal tubular cells Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.DNA damage response in cisplatin-induced nephrotoxicity.RING finger protein 31 promotes p53 degradation in breast cancer cells.A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma.Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway.IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation.The cell cycle and acute kidney injury.Renoprotective approaches and strategies in acute kidney injury Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer.Activation and involvement of p53 in cisplatin-induced nephrotoxicity.Pathophysiology of acute kidney injury Transient protein-protein interactions.Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma.Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy.The clinical development of p53-reactivating drugs in sarcomas - charting future therapeutic approaches and understanding the clinical molecular toxicology of Nutlins.Nutlin-3, A P53-Mdm2 Antagonist For Nasopharyngeal Carcinoma Treatment.Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia.Cyclotherapy: opening a therapeutic window in cancer treatment.Overexpression of p18INK⁴C in LLC-PK1 cells increases resistance to cisplatin-induced apoptosis.Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells.Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis.

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P2860

Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.

http://www.wikidata.org/entity/Q33808489

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

@ast

Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

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type

label

Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

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Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

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prefLabel

Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

@ast

Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

@en

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Journal of Biological Chemistry

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Nutlin-3 protects kidney cells ...... uppressing Bax/Bak activation.

@en

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Kurt Degenhardt

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Man Jiang

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Navjotsin Pabla

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Robert F Murphy

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Tianxin Yang

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Xiao-Ming Yin

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Zheng Dong

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P2860

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

Cell death: critical control points

Hdmx modulates the outcome of p53 activation in human tumor cells

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

Bax and Bak independently promote cytochrome C release from mitochondria

The expanding role of mitochondria in apoptosis

The pathophysiology of mitochondrial cell death

Cisplatin: mode of cytotoxic action and molecular basis of resistance

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