Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
about
Meprins, membrane-bound and secreted astacin metalloproteinasesShort forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusionHuman B-type natriuretic peptide is not degraded by meprin A.Meprin A metalloproteinase and its role in acute kidney injury.The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1betaMeprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin.Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.Meprin metalloproteases inactivate interleukin 6.
P2860
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P2860
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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name
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@en
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@nl
type
label
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@en
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@nl
prefLabel
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@en
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@nl
P2093
P2860
P356
P1433
P1476
Human and mouse homo-oligomeri ...... e and inhibitor specificities.
@en
P2093
Greg P Bertenshaw
John E Bylander
Judith S Bond
P2860
P304
P356
10.1515/BC.2007.156
P577
2007-11-01T00:00:00Z