The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
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Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3Meprins, membrane-bound and secreted astacin metalloproteinasesStructural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneEvaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkersDental enamel development: proteinases and their enamel matrix substratesMetalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrateRole of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coliSpinning gland transcriptomics from two main clades of spiders (order: Araneae)--insights on their molecular, anatomical and behavioral evolutionEnhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.Activation of the epithelial sodium channel by the metalloprotease meprin β subunit.Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substratesVillin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusionOrigin and Diversification of Meprin Proteases.Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migrationThe substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP)Meprin A metalloproteinase and its role in acute kidney injury.Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1betaMeprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.Metastasis of ovarian cancer is mediated by kallikrein related peptidases.Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.Proteolytic processing and inactivation of CCL2/MCP-1 by meprins.Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion.Adaptive Evolution Favoring KLK4 Downregulation in East Asians.
P2860
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P2860
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The alpha and beta subunits of ...... liferation and differentiation
@ast
The alpha and beta subunits of ...... liferation and differentiation
@en
The alpha and beta subunits of ...... liferation and differentiation
@nl
type
label
The alpha and beta subunits of ...... liferation and differentiation
@ast
The alpha and beta subunits of ...... liferation and differentiation
@en
The alpha and beta subunits of ...... liferation and differentiation
@nl
prefLabel
The alpha and beta subunits of ...... liferation and differentiation
@ast
The alpha and beta subunits of ...... liferation and differentiation
@en
The alpha and beta subunits of ...... liferation and differentiation
@nl
P2093
P356
P1476
The alpha and beta subunits of ...... liferation and differentiation
@en
P2093
Annica Vlad
Christoph Becker-Pauly
Daniel Lottaz
Erwin E Sterchi
Heiko Traupe
Karin Aufenvenne
Markus Höwel
Mekdes Debela
Tatjana Walker
Viktor Magdolen
P2888
P304
P356
10.1038/SJ.JID.5700675
P407
P577
2007-05-01T00:00:00Z
P5875
P6179
1041509963