Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor.
about
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptorStructural and functional conservation of key domains in InsP3 and ryanodine receptorsTyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel openingFlexible architecture of IP3R1 by Cryo-EMBinding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.Calcium-dependent conformational changes in inositol trisphosphate receptors.Toward a high-resolution structure of IP₃R channel.Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1.CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.When worlds collide: IP(3) receptors and the ERAD pathway.Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.IP(3) receptors: toward understanding their activation.Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells: from molecular mechanism to behavior.Themes and variations in ER/SR calcium release channels: structure and function.Structural organization of signalling to and from IP3 receptors.Structure of IP3R channel: high-resolution insights from cryo-EM.Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.Synthetic partial agonists reveal key steps in IP3 receptor activation.Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies using cysteine substitution mutagenesis.Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.Activation of IP(3) receptors by synthetic bisphosphate ligandsThe conserved Arg241-Glu439 salt bridge determines flexibility of the inositol 1,4,5-trisphosphate receptor binding core in the ligand-free state.
P2860
Q27673043-5EC5425C-7CA9-444F-9284-AF00ACCF8F7BQ27676937-F44353AC-330A-45F0-93E6-2E3231A04DD9Q28594466-033AEEB2-8E4D-4DC0-91BB-70AEEED3BF79Q30503400-BDB4754B-24DA-4D58-A9BE-A20AE9B05B26Q33890836-2402A0AE-9B72-4411-8F91-694E6AB1C231Q34042834-FDB45555-E5C0-4A30-BE6E-E3D5113CBE3AQ34173862-F09A767B-3CCC-493B-8E90-5875F8609079Q34879899-9DEEE64D-09B4-473A-8BE8-A9AF8ECC9ED3Q36884135-A17F5E84-A19D-47B9-9549-63C430D1D35BQ37364711-8EA216E6-E282-4AC0-9F14-644B06777CDDQ37607171-2CB24B2A-9472-4889-9D30-980D7C13EF78Q37761443-EA62521A-F6BF-484D-8384-6CFCBE8060EDQ37803478-E09C9C4E-A6C8-4EAF-867E-39C022A5451FQ37893988-BA578AFA-C764-4935-902F-1B6C57311311Q38065938-851534D6-88DB-4373-99BF-9BD4DE310C2DQ38180759-3ABB17B8-27A3-4EB4-817F-205A59FAE7AFQ38670656-4240FE68-7919-4AEC-91FD-7323C9CECC01Q39272143-70CA1E77-2529-4188-B307-74F28DE941B5Q40523623-DD797B5B-B6E2-4903-9869-67849CA9C9BBQ41976206-9B1E8090-DBB0-4844-894E-925DC074ED16Q42150932-11007CD4-9F42-4C28-93B4-A8966C640701Q42737227-94C1FA3D-48B2-49EE-8F74-4DA0CE64F747Q51054355-B202359E-7A90-49EB-84F2-E13F7EF0F58C
P2860
Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@en
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@nl
type
label
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@en
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@nl
prefLabel
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@en
Ligand-induced conformational ...... 1,4,5-trisphosphate receptor.
@nl
P2093
P50
P1476
Ligand-induced conformational ...... l 1,4,5-trisphosphate receptor
@en
P2093
Horea Porumb
Ivan Bosanac
Jennifer Ito
Jenny Chan
Katsuhiko Mikoshiba
Takayuki Michikawa
Tapas K Mal
P304
P356
10.1016/J.JMB.2007.08.057
P407
P577
2007-08-29T00:00:00Z