about
Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazoneStructure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and diseaseThe novel 2Fe–2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domainAllostery in the ferredoxin protein motif does not involve a conformational switchMutation of the His ligand in mitoNEET stabilizes the 2Fe–2S cluster despite conformational heterogeneity in the ligand environmentAllosteric control in a metalloprotein dramatically alters function.A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor propertiesNutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugsBinding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET.Resonance Raman studies of the (His)(Cys)3 2Fe-2S cluster of MitoNEET: comparison to the (Cys)4 mutant and implications of the effects of pH on the labile metal centerIntegrated photosystem II-based photo-bioelectrochemical cells.Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor proteinThe Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein.Interactions between mitoNEET and NAF-1 in cells.Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cellsNAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clustersPhylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates.Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.Photosynthetic reaction center-functionalized electrodes for photo-bioelectrochemical cells.Discovering Novel and Diverse Iron-Chelators in Silico.Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.Engineering the redox potential over a wide range within a new class of FeS proteins.Structural basis for the thermostability of ferredoxin from the cyanobacterium Mastigocladus laminosus.Purification, crystallization and preliminary X-ray analysis of ferredoxin isolated from thermophilic cyanobacterium Mastigocladus laminosus.Generation of photocurrents by bis-aniline-cross-linked Pt nanoparticle/photosystem I composites on electrodes.Photosystem I (PSI)/Photosystem II (PSII)-based photo-bioelectrochemical cells revealing directional generation of photocurrents.The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.Molecular Dynamics Simulations of the [2Fe-2S] Cluster-Binding Domain of NEET Proteins Reveal Key Molecular Determinants That Induce Their Cluster Transfer/Release.GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome.
P50
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P50
name
Rachel Nechushtai
@ast
Rachel Nechushtai
@en
Rachel Nechushtai
@es
Rachel Nechushtai
@nl
type
label
Rachel Nechushtai
@ast
Rachel Nechushtai
@en
Rachel Nechushtai
@es
Rachel Nechushtai
@nl
prefLabel
Rachel Nechushtai
@ast
Rachel Nechushtai
@en
Rachel Nechushtai
@es
Rachel Nechushtai
@nl