mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.

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The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

P2860

Q50050282-73392551-E03A-4162-ACB4-175775C33394

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mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.

Item

http://www.wikidata.org/entity/Q47140692

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2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年学术文章

@wuu

2016年学术文章

@zh

2016年学术文章

@zh-cn

2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

@zh-sg

2016年學術文章

@yue

2016年學術文章

@zh-hant

name

mTORC2 (Rictor) in Alzheimer's ...... Rat Primary Cortical Neurons.

@en

mTORC2

@nl

type

Item

label

mTORC2 (Rictor) in Alzheimer's ...... Rat Primary Cortical Neurons.

@en

mTORC2

@nl

prefLabel

mTORC2 (Rictor) in Alzheimer's ...... Rat Primary Cortical Neurons.

@en

mTORC2

@nl

P1476

mTORC2 (Rictor) in Alzheimer's ...... Rat Primary Cortical Neurons.

@en

P2093

Bumsup Kwon

http://www.w3.org/2001/XMLSchema#string

Cynthia A Lemere

http://www.w3.org/2001/XMLSchema#string

Han-Kyu Lee

http://www.w3.org/2001/XMLSchema#string

Henry W Querfurth

http://www.w3.org/2001/XMLSchema#string

Kyohei Itamura

http://www.w3.org/2001/XMLSchema#string

Suzanne de la Monte

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

SIRT1 negatively regulates the mammalian target of rapamycin

Activation of mTORC2 by association with the ribosome

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

P304

1015-1036

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scholarly article

P356

10.3233/JAD-161029

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Austin Y Ha

P577

2016-12-30T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28035937

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

5577393

http://www.w3.org/2001/XMLSchema#string

mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.

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P2860

P2860

mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.

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