Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.
about
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseasesBase excision repair and cancerDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationSequence-specific cleavage of dsRNA by Mini-III RNaseDioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liverGenistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrestIntegrated genomics of susceptibility to alkylator-induced leukemia in miceFunctional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damageNeurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.Folate deficiency regulates expression of DNA polymerase β in response to oxidative stressMechanism and regulation of class switch recombinationA novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary AgentsOxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous miceBase excision repair in the mammalian brain: implication for age related neurodegenerationEmbryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.Spontaneous mutagenesis is enhanced in Apex heterozygous mice.Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex.Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity.Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency.The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry.A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.APE1 deficiency promotes cellular senescence and premature aging features.
P2860
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P2860
Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Apurinic/apyrimidinic endonucl ...... ependent base excision repair.
@en
type
label
Apurinic/apyrimidinic endonucl ...... ependent base excision repair.
@en
prefLabel
Apurinic/apyrimidinic endonucl ...... ependent base excision repair.
@en
P2093
P2860
P356
P1476
Apurinic/apyrimidinic endonucl ...... dependent base excision repair
@en
P2093
Ahmad R Heydari
Diane C Cabelof
Errol C Friedberg
Julian J Raffoul
Jun Nakamura
P2860
P304
18425-18433
P356
10.1074/JBC.M313983200
P407
P577
2004-02-18T00:00:00Z