Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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P1476

Exceptionally high-affinity Ras binders that remodel its effector domain

@en

P2093

Gregory L Verdine

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Michael A Durney

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Paige K Swanson

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Sam Y Jiang

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Seung-Joo Lee

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So Youn Shim

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P2860

The structural basis of the activation of Ras by Sos

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Dynamic properties of the Ras switch I region and its importance for binding to effectors

Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants

P304

3265-3280

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P31

scholarly article

P356

10.1074/JBC.M117.816348

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

293

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P50

John McGee

P577

2017-12-27T00:00:00Z

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P698

29282294

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P932

5836121

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