(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

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(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

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(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

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(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

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P1476

(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

@en

P2093

Alexis Rivas

http://www.w3.org/2001/XMLSchema#string

Claudio Hetz

http://www.w3.org/2001/XMLSchema#string

Rodrigo Pérez-Arancibia

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P2860

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.

PERK activation mitigates tau pathology in vitro and in vivo.

The role of endoplasmic reticulum stress in human pathology.

ER stress and the unfolded protein response in neurodegeneration.

The integrated stress response.

Fine-tuning PERK signaling for neuroprotection.

P304

97-100

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P31

scholarly article

editorial

P356

10.1080/14728222.2018.1420169

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2017-12-20T00:00:00Z

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P698

29260915

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