Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
about
Molecular cloning and promoter analysis of downregulated in adenoma (DRA)Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestineHepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivoGata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during developmentPIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation.GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine.GATA4 is essential for jejunal function in miceCooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line.GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature miceConditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactorsTranscription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.Characterization of expression in mice of a transgene containing 3.3 kb of the human lactase-phlorizin hydrolase (LPH) 5' flanking sequenceGATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon.GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa.Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine.Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome.Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium.Molecular mechanisms of Barrett's esophagus.The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system.Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene.Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation.T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.
P2860
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P2860
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@en
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@nl
type
label
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@en
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@nl
prefLabel
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@en
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@nl
P2093
P2860
P356
P1476
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
@en
P2093
Anna Musters
Caroline E Hogen Esch
Evelien de Jong
Francois Boudreau
Gary P Swain
Herbert M van Wering
Lauren N Dowling
Naomi de Jong
Richard J Grand
Robert K Montgomery
P2860
P304
P356
10.1152/AJPGI.00150.2004
P577
2004-06-03T00:00:00Z