about
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpointTargeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principlesDesigning Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2Structural basis for bivalent Smac-mimetics recognition in the IAP protein familyRecognition of Smac-mimetic compounds by the BIR domain of cIAP1Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-MimeticAtaxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibEGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies.Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents.Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiencyAntitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases.Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells.Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents.MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors.DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patientsTargeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer TreatmentStructure-based design and molecular profiling of Smac-mimetics selective for cellular IAPsImmune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.Infiltrating mast cell-mediated stimulation of estrogen receptor activity in breast cancer cells promotes the luminal phenotypeWhen Failure Is Worse Than Giving Up: The Case of CTL
P50
Q24324057-7A31D740-B783-46B6-8E41-E12F19DB7EBFQ27652497-4318AD08-A40B-4853-BD09-86A42A2BE7FDQ27652810-B085B55A-5BDB-49F7-9EFE-0612B97A0C88Q27655218-C0F353D8-D241-445C-8D2E-1996660E0A88Q27665119-43297764-4DA4-4FD6-8262-6564251FC78BQ27675179-D1B09B0D-4427-47DF-9298-D18EFF0E88E0Q27919672-3625F326-50A7-4FBC-9C3E-4D03E2AF55D2Q28289589-8E8CC77E-2F3F-47CA-9BA7-3D3E8434755FQ33292501-7F3CD08F-AC6F-4327-88A9-EAEAA4F67210Q33906039-CC99F9B3-EEFF-4DA3-A267-0CC20A8E5334Q34149887-1B426FED-0D04-48D0-A96D-A2C5D4E6F68EQ35215959-8EAFC20C-4A17-4456-A169-279D0E2DF1E5Q37357090-AF47A2A9-B976-429C-99C0-28B9D0EA8F38Q38605930-546E8995-38D4-4147-B096-096B8A18F6A1Q38723407-58BE5E81-3899-4B4B-8E21-07E42A653C90Q38748928-52B8D7BA-90BE-4431-B317-AD378889547CQ39003639-57759E7D-FA54-4D88-8A6A-A38E91F39215Q39003789-28B24BFD-5C28-488F-A697-5DDAE062316FQ39260309-D9B25471-6760-497B-9CB2-C006464DD8A3Q39395317-3BB381B4-51B8-4AF3-B246-8215A4999941Q39682910-CAA6CC87-8266-4E2C-927D-833F91DC42C1Q39822939-2BAD4098-D79C-4245-8C37-56C879B3F4D7Q39859634-A0C95E2C-8D26-4710-B790-7E52652B83C4Q39881890-7881351F-E6CC-4F7F-A7F7-F894289959F0Q42275527-DF2E6385-5782-4FA6-9818-8EDF6258ADC9Q42771888-236F9AFA-F978-4D00-BD88-519ACACB302CQ44134106-3DD3C80F-9B11-4439-AC01-96470ED177B6Q47174310-70592BEF-6C76-4FE8-A08F-BFEFD82666E7Q47739870-FED6F1EE-5673-43A0-862B-BE2F5AE01531Q47976582-9F12A5DE-9F61-449D-BD2D-8A2A24B7F4BDQ51039553-4A159B1F-3441-4A5E-97D9-55DAF6EE708AQ52646457-F8BFB657-CD92-4376-AA3B-8F63DB2129A6Q52718170-C60E8261-1507-4FE2-8869-343235202078Q53151255-4BD4F4F3-6D01-4E50-AEFB-AEEF5D763528Q61444494-80500BC5-CC19-49FD-B2FA-62E1349321DEQ61809001-E83A3E96-8910-4924-A97C-0EE5E44C27FFQ63436398-147DE05C-F74B-4079-AA6D-D415B0BD10C0Q64967509-B7B820E4-FC2B-4259-9B53-DA4DF469330CQ90369537-A3A85E1C-74F7-4C38-8A6E-E75A5D6935BAQ93109235-9B7E3EF2-EBD7-4B06-AC74-72DA923781BC
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Daniele Lecis
@ast
Daniele Lecis
@en
Daniele Lecis
@es
Daniele Lecis
@nl
Daniele Lecis
@sl
type
label
Daniele Lecis
@ast
Daniele Lecis
@en
Daniele Lecis
@es
Daniele Lecis
@nl
Daniele Lecis
@sl
prefLabel
Daniele Lecis
@ast
Daniele Lecis
@en
Daniele Lecis
@es
Daniele Lecis
@nl
Daniele Lecis
@sl
P1053
C-2113-2017
P106
P1153
23973036800
P21
P31
P3829
P496
0000-0002-0564-0563