Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.
about
Small-molecule SMAC mimetics as new cancer therapeuticsIAP antagonists induce anti-tumor immunity in multiple myeloma.Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.TRAF3: a novel tumor suppressor gene in macrophages.The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.Impact of inhibitor of apoptosis proteins on immune modulation and inflammation.Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.IAP antagonization promotes inflammatory destruction of vascular endothelium.Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance.
P2860
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P2860
Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Smac mimetics induce inflammat ...... odulating macrophage activity.
@en
Smac mimetics induce inflammat ...... odulating macrophage activity.
@nl
type
label
Smac mimetics induce inflammat ...... odulating macrophage activity.
@en
Smac mimetics induce inflammat ...... odulating macrophage activity.
@nl
prefLabel
Smac mimetics induce inflammat ...... odulating macrophage activity.
@en
Smac mimetics induce inflammat ...... odulating macrophage activity.
@nl
P2093
P2860
P50
P356
P1476
Smac mimetics induce inflammat ...... odulating macrophage activity.
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2013.449
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P577
2013-11-14T00:00:00Z
P5875
P6179
1036090607