The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans.
about
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course studyBrain imaging and functional gastrointestinal disorders: has it helped our understanding?Prostanoid receptor antagonists: development strategies and therapeutic applicationsMultimodal pain stimulation of the gastrointestinal tract.Nonerosive Reflux Disease (NERD) - An Update.Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cellsIncrease in gastric acid-induced afferent input to the brainstem in mice with gastritis.RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists.Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acidGastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets.Experimental human pain models: a review of standardised methods for preclinical testing of analgesics.Review article: drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders--the clinical evidence.Gut pain & visceral hypersensitivityThe heart and the oesophagus: intimate relations.Peripheral and central mechanisms of visceral sensitization in man.Current advances in the diagnosis and treatment of nonerosive reflux disease.Effect of esophageal acid exposure on the cortical swallowing network in healthy human subjectsOptimizing the early phase development of new analgesics by human pain biomarkers.Mechanisms of reflux perception in gastroesophageal reflux disease: a review.Translational pain biomarkers in the early development of new neurotherapeutics for pain management.Established and Emerging Treatment Options for Functional Heartburn and Chest Pain.Modulation of bladder function by prostaglandin EP3 receptors in the central nervous system.Effects of the concentration and frequency of acid infusion on the development and maintenance of esophageal hyperalgesia in a human volunteer model.Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal.Evidence of a role for GTP cyclohydrolase-1 in visceral pain.Perceptual wind-up in the human oesophagus is enhanced by central sensitisation.Sensitization of mesenteric afferents to chemical and mechanical stimuli following systemic bacterial lipopolysaccharide.Acid reflux episodes sensitize the esophagus to perception of weakly acidic and mixed reflux in non-erosive reflux disease patients.Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers.Parietal peritoneal closure and persistent postcesarean pain.Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity.Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats.Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification - evidence of central sensitization.A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial.
P2860
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P2860
The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
The prostaglandin E2 receptor- ...... in hypersensitivity in humans.
@en
The prostaglandin E2 receptor-1
@nl
type
label
The prostaglandin E2 receptor- ...... in hypersensitivity in humans.
@en
The prostaglandin E2 receptor-1
@nl
prefLabel
The prostaglandin E2 receptor- ...... in hypersensitivity in humans.
@en
The prostaglandin E2 receptor-1
@nl
P2093
P356
P1433
P1476
The prostaglandin E2 receptor- ...... in hypersensitivity in humans.
@en
P2093
Anthony R Hobson
Clifford J Woolf
David G Thompson
Jim Growcott
Qasim Aziz
Sanchoy Sarkar
P356
10.1053/GAST.2003.50022
P407
P577
2003-01-01T00:00:00Z