Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening.
about
Modulating splicing with small molecular inhibitors of the spliceosomeA synthetic entry to pladienolide B and FD-895Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivativesGarbled messages and corrupted translations.Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619.Natural products to drugs: natural product-derived compounds in clinical trials.High antitumor activity of pladienolide B and its derivative in gastric cancerDesign, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A.Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitorSmall Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyRuthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stagesMicroregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitorGenomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Splicing in oncogenesis and tumor suppression.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Alternative splicing in cancer: implications for biology and therapy.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.Design and synthesis of analogues of natural products.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives."Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues.Pursuing the unlimited potential of microorganisms-progress and prospect of a fermentation company.Therapeutic targeting of splicing in cancer.Biological validation that SF3b is a target of the antitumor macrolide pladienolide.Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.Gombapyrones, new alpha-pyrone metabolites produced by Streptomyces griseoruber Acta 3662.A Challenging Pie to Splice: Drugging the Spliceosome.Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.Splicing factor SF3b as a target of the antitumor natural product pladienolide.
P2860
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P2860
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Pladienolides, new substances ...... tion, isolation and screening.
@en
Pladienolides, new substances ...... tion, isolation and screening.
@nl
type
label
Pladienolides, new substances ...... tion, isolation and screening.
@en
Pladienolides, new substances ...... tion, isolation and screening.
@nl
prefLabel
Pladienolides, new substances ...... tion, isolation and screening.
@en
Pladienolides, new substances ...... tion, isolation and screening.
@nl
P2093
P1476
Pladienolides, new substances ...... tion, isolation and screening.
@en
P2093
Kazuyuki Dobashi
Motoko Matsufuji
Naoto Kawamura
Takashi Sakai
Tomohiro Sameshima
Yoshiharu Mizui
P304
P356
10.7164/ANTIBIOTICS.57.173
P577
2004-03-01T00:00:00Z