Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies.

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Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Assessment of multiple cytochr ...... reaction phenotyping studies.

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Assessment of multiple cytochr ...... reaction phenotyping studies.

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Assessment of multiple cytochr ...... reaction phenotyping studies.

@en

Assessment of multiple cytochr ...... reaction phenotyping studies.

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Assessment of multiple cytochr ...... reaction phenotyping studies.

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Assessment of multiple cytochr ...... reaction phenotyping studies.

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P1476

Assessment of multiple cytochr ...... reaction phenotyping studies.

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P2093

Kanako Yajima

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Kanami Shimura

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Kazuhide Iwasaki

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Masahiro Utoh

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Masaki Takada

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Mikiko Hikawa

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Norie Murayama

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Yu Ishii

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P2860

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant.

Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data.

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes.

Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation.

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.

P304

116-121

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P31

scholarly article

P356

10.1002/BDD.2115

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Hiroshi Yamazaki

Yasuhiro Uno

P577

2017-11-14T00:00:00Z

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P698

29136681

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