Interleukin-10 and the interleukin-10 receptorAntigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokinesType I interferons in infectious diseaseDetectable changes in the blood transcriptome are present after two weeks of antituberculosis therapyThe human immune response to tuberculosis and its treatment: a view from the bloodABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responsesA CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisFriend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development.Checkpoints for regulation of development and IFN-gamma production by Th1 cells in TCR-transgenic models.Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis.The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro.Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout miceImmunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection.The molecular basis of T helper 1 and T helper 2 cell differentiation.Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in miceReversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patientsType I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.Brigitte Askonas (1923-2013).Further checkpoints in Th1 development.NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activationTranscriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancersInterleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines.Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei.Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosisPolymerase chain reaction for detection of cytokine gene expression.Biological properties of interleukin 10.Remembering Ralph SteinmanTargeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cellsIL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infectionDevelopment and function of T helper 1 cells.GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells.Regulatory T cells and mechanisms of immune system control.Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling.IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damageEnhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
P50
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P50
description
British immunologist
@en
Brits immunologe
@nl
inmunóloga británica
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عالمة مناعة من المملكة المتحدة
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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Anne O'Garra
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