about
Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complexCofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientationStructure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenaseCrystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteinsThe Ternary Structure of the Double-headed Arrowhead Protease Inhibitor API-A Complexed with Two Trypsins Reveals a Novel Reactive Site ConformationBinary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol productionStructure Analysis of a New Psychrophilic Marine ProteaseCrystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission PathwayHuman 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activityHuman 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growthStructural Insight into NS5 of Zika Virus Leading to the Discovery of MTase InhibitorsPurification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitorsCrystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle.Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cellsComparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration.Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer.Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.Molecular therapy of breast cancer: progress and future directions.A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown.17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity.Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane-3β,17β-diol with estrogen and androgen receptors: a combined binding and cell study.Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase.Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.Human 17 beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization.Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.The glutamyl-tRNA synthetase of Escherichia coli contains one atom of zinc essential for its native conformation and its catalytic activity.
P50
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P50
description
biochemist, researcher and professor at Université Laval
@en
biochimiste, chercheur et professeur à l'Université Laval
@fr
wetenschapper
@nl
հետազոտող
@hy
name
Sheng-Xiang Lin
@ast
Sheng-Xiang Lin
@en
Sheng-Xiang Lin
@es
Sheng-Xiang Lin
@fr
Sheng-Xiang Lin
@nl
Sheng-Xiang Lin
@sl
type
label
Sheng-Xiang Lin
@ast
Sheng-Xiang Lin
@en
Sheng-Xiang Lin
@es
Sheng-Xiang Lin
@fr
Sheng-Xiang Lin
@nl
Sheng-Xiang Lin
@sl
prefLabel
Sheng-Xiang Lin
@ast
Sheng-Xiang Lin
@en
Sheng-Xiang Lin
@es
Sheng-Xiang Lin
@fr
Sheng-Xiang Lin
@nl
Sheng-Xiang Lin
@sl
P106
P69
P1153
7407153884
P1960
F7ZJctkAAAAJ
P21
P31
P496
0000-0001-9149-375X
P569
2000-01-01T00:00:00Z
P6634
sheng-xiang-lin-92299079