Perinatal lethality of Par4(-/-) mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function.

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Perinatal lethality of Par4(-/-) mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function.

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http://www.wikidata.org/entity/Q47727892

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2017 nî lūn-bûn

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2017年の論文

@ja

2017年学术文章

@wuu

2017年学术文章

@zh

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

@zh-hant

name

Perinatal lethality of Par4

@nl

Perinatal lethality of Par4(-/ ...... et thrombin receptor function.

@en

type

Item

label

Perinatal lethality of Par4

@nl

Perinatal lethality of Par4(-/ ...... et thrombin receptor function.

@en

prefLabel

Perinatal lethality of Par4

@nl

Perinatal lethality of Par4(-/ ...... et thrombin receptor function.

@en

P1476

Perinatal lethality of Par4(-/ ...... et thrombin receptor function.

@en

P2093

Shauna L French

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P2860

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

Role of thrombin signalling in platelets in haemostasis and thrombosis.

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

Prothrombin deficiency results in embryonic and neonatal lethality in mice.

Approval of the first protease-activated receptor antagonist: Rationale, development, significance, and considerations of a novel anti-platelet agent.

Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.

Protection against thrombosis in mice lacking PAR3.

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.

A role for thrombin receptor signaling in endothelial cells during embryonic development.

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

P304

196-198

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P31

scholarly article

P356

10.1080/09537104.2017.1349310

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Justin R Hamilton

P577

2017-09-29T00:00:00Z

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P698

28960148

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